Professor Matthew Lambon Ralph FRSLT (hons), FBPsS
Professor of Cognitive Neuroscience & Associate Vice-President (Research)
- Email: firstname.lastname@example.org
- Telephone: +44 (0)161 275 2551
- Alternative Telephone: +44 (0)161 276 0441 (PA: Louise Twelvetrees)
- Fax: +44 (0)161 275 2873
See the Neuroscience and Aphasia Research Unit (NARU) website for more details on my research and NARU.
Google Citations homepage: http://scholar.google.com/citations?user=8LrzRnAAAAAJ
Thomson Reuter - Research ID homepage: http://www.researcherid.com/rid/A-1695-2009
Scopus Author ID: 7003333514
Our research makes use of four key methodologies: neuropsychology, computational models (models that can mimic neural organisation in their construction but also produce target behaviours), transcranial magnetic stimulation (TMS), structural and functional neuroimaging. The various research projects can be summarised under three themes:
(1) Semantic memory : various interlinked projects explore the nature and neural underpinnings of semantic memory or conceptual knowledge, including category-specific disorders. This uses data from semantic dementia, herpes simplex virus encephalitis (HSVE), aphasia after CVA and temporal lobe resection for epilepsy for the neuropsychological investigations and is complemented by TMS, fMRI and MR tractography studies.
(2) Language : there are several ongoing projects exploring different aspects of language production and comprehension, and their neural bases. For neuropsychology, these include a direct comparison of fluent and non-fluent varieties of progressive and non-progressive aphasia; acquired dyslexias and dysgraphias; verb morphology deficits; and verbal short-term memory deficits. We also conduct parallel studies in neurological intact studies utilising experimental psycholingistics, TMS, computational modelling and fMRI studies.
(3) Recovery, rehabilitation and neuroplasticity : As well as concentrating on the nature of chronic and progressive cognitive and language deficits, the third theme is devoted to the study of the neural and cognitive principles that guide recovery and rehabilitation. This includes active rehabilitation programmes, longitudinal neuropsychological assessment of recovery, computational models of neuroplasticity and parallel functional imaging studies of patients.
I obtained my PhD from York University and then worked at the MRC Cognition and Brain Sciences Unit (Cambridge). I moved from there to the University of Bristol, Department of Experimental Psychology, as a Lecturer. I came to Manchester in 2001 as Professor of Cognitive Neuroscience within the School of Psychological Sciences. I am also Associate Vice-President (Research) and Director of the Manchester Doctoral College at the University. I am an Action Editor for Neuropsychological Rehabilitation and on the editorial boards for Cognitive Neuropsychology, Memory, International Journal of Language & Communication Disorders, Alzheimer's Research & Therapy, Psychologia, and Neurocase. I was the President of The British Neuropsychological Society (2010-12) and the Vice-Chair for the British Aphasiology Society (2000-2005). I was made a Fellow (hons) of the Royal College of Speech and Language Therapists in 2003, Fellow of the British Psychological Society in 2012 and an Honorary Research Professor of the University of Málaga in 2014. I am also a Senior Investigator Emeritus for the NIHR, and awarded the BPS President's Award in 2015.
Collaborators and affiliated staff
- Prof. Manabu Ikeda
Kumamoto University Hospital
- Prof. Beth Jefferies
University of York
- Dr. Riki Matsumoto
- Prof. Jay McClelland
- Prof. Karalyn Patterson
MRC Cognition and Brain Sciences Unit, Cambridge
- Prof. Tim Rogers
University of Madison-Wisconsin
- Dr. Satoru Saito
Butler, R., Lambon Ralph, M. & Woollams, A (2014).
Capturing multidimensionality in stroke aphasia: mapping principal behavioural components to neural structures. Brain, 137(Pt 12), 3248-66. eScholarID:246284 | PMID:25348632 | DOI:10.1093/brain/awu286
Humphreys, G. & Lambon Ralph, M (2014).
Lambon Ralph, M (2014).
Shimotake, A., Matsumoto, R., Ueno, T., Kunieda, T., Saito, S., Hoffman, P., Kikuchi, T., Fukuyama, H., Miyamoto, S., Takahashi, R., Ikeda, A. & Lambon Ralph, M (2014).
Direct Exploration of the Role of the Ventral Anterior Temporal Lobe in Semantic Memory: Cortical Stimulation and Local Field Potential Evidence From Subdural Grid Electrodes. Cereb Cortex, eScholarID:246297 | PMID:25491206 | DOI:10.1093/cercor/bhu262
A.C. Schapiro, J.L. McClelland, S.R. Welbourne, T.T. Rogers, & M.A. Lambon Ralph. (2013).
K.A. Noonan, E. Jefferies, M. Visser, & M.A. Lambon Ralph. (2013).
Going beyond inferior prefrontal involvement in semantic control: Evidence for the additional contribution of dorsal angular gyrus and posterior middle temporal cortex. Journal of Cognitive Neuroscience, 25, 1824-1850. eScholarID:209913 | DOI:doi:10.1162/jocn_a_00442
Binney, R., Parker, G. & Lambon Ralph, M (2012).
Convergent connectivity and graded specialization in the rostral human temporal lobe as revealed by diffusion-weighted imaging probabilistic tractography. J Cogn Neurosci, 24(10), 1998-2014. eScholarID:246290 | PMID:22721379 | DOI:10.1162/jocn_a_00263
Cloutman, L., Binney, R., Drakesmith, M., Parker, G. & Lambon Ralph, M (2012).
The variation of function across the human insula mirrors its patterns of structural connectivity: evidence from in vivo probabilistic tractography. Neuroimage, 59(4), 3514-21. eScholarID:163336 | PMID:22100771 | DOI:10.1016/j.neuroimage.2011.11.016
M. A. Lambon Ralph, S. Ehsan, G. A. Baker and T. T. Rogers. (2012).
M. Visser, E. Jefferies, K. Embleton, & M.A. Lambon Ralph. (2012).
Both the middle temporal gyrus and the ventral anterior temporal area are crucial for multimodal semantic processing: Distortion-corrected fMRI evidence for a double gradient of information convergence in the temporal lobes. Journal of Cognitive Neuroscience, 24, 1766-1778. eScholarID:164237 | DOI:10.1162/jocn_a_00244
Noonan, K., Pryer, L., Jones, R., Burns, A. & Lambon Ralph, M (2012).
A direct comparison of errorless and errorful therapy for object name relearning in Alzheimer's disease. Neuropsychol Rehabil, 22(2), 215-34. eScholarID:157976 | PMID:22376314 | DOI:10.1080/09602011.2012.655002
Richard J. Binney, Geoffrey J. M. Parker, and Matthew A. Lambon Ralph. (2012).
Convergent Connectivity and Graded Specialization in the Rostral Human Temporal Lobe as Revealed by Diffusion-Weighted Imaging Probabilistic Tractography. Journal of Cognitive Neuroscience, 24(10), 1998-2014. eScholarID:171248 | DOI:10.1162/jocn_a_00263
Robson, H., Sage, K. & Lambon Ralph, M (2012).
Wernicke's aphasia reflects a combination of acoustic-phonological and semantic control deficits: A case-series comparison of Wernicke's aphasia, semantic dementia and semantic aphasia. Neuropsychologia, 50(2), 266-75. eScholarID:154797 | PMID:22178742 | DOI:10.1016/j.neuropsychologia.2011.11.021
C. Whitney, M. Kirk, J. O’Sullivan, M.A. Lambon Ralph, & E. Jefferies. (2011).
The neural organization of semantic control: TMS evidence for a distributed network in left inferior frontal and posterior middle temporal gyrus. Cerebral Cortex, 21, 1066-1075. eScholarID:122803 | DOI:10.1093/cercor/bhq180
M. A. Lambon Ralph, S. Ehsan, G. A. Baker and T. T. Rogers. (2011).
M. Visser, M. A. Lambon Ralph. (2011).
Differential contributions of the ventral anterior temporal lobe and the anterior superior temporal gyrus to semantic processes. Journal of Cognitive Neuroscience, 23, 3121-3131. eScholarID:135151 | DOI:doi:10.1162/jocn_a_00007
T. Ueno, S. Saito, T. T. Rogers and M. A. Lambon Ralph. (2011).
Lichtheim 2: Synthesizing Aphasia and the Neural Basis of Language in a Neurocomputational Model of the Dual Dorsal-Ventral Language Pathways. Neuron, 72(2), 385. eScholarID:130795 | DOI:10.1016/j.neuron.2011.09.013
G. Pobric, E. Jefferies, & M.A. Lambon Ralph. (2010).
M. Visser, E. Jefferies, and M. A. Lambon Ralph. (2010).
M.A. Lambon Ralph, C. Snell, J.K. Fillingham, P. Conroy, & K. Sage. (2010).
Predicting the outcome of anomia therapy for people with aphasia post CVA: Both language and cognitive status are key predictors. Neuropsychological Rehabilitation, 20, 289-305. eScholarID:77421 | DOI:10.1080/09602010903237875
M.A. Lambon Ralph, L. Cipolotti, F. Manes, & K. Patterson. (2010).
Matthew A Lambon Ralph, Karen Sage, Roy W Jones, Emily J Mayberry. (2010).
Coherent concepts are computed in the anterior temporal lobes. Proceedings of the National Academy of Sciences of the United States of America, 107(6), 2717-2722. eScholarID:79190 | DOI:10.1073/pnas.0907307107
R.J. Binney, K.V. Embleton, E. Jefferies, G.J.M. Parker, & M.A. Lambon Ralph. (2010).
The Ventral and Inferolateral Aspects of the Anterior Temporal Lobe Are Crucial in Semantic Memory: Evidence from a Novel Direct Comparison of Distortion-Corrected fMRI, rTMS, and Semantic Dementia. Cerebral Cortex, 20(11), 2728-2738. eScholarID:92503 | DOI:10.1093/cercor/bhq019
Lambon Ralph MA, Pobric GG, Jefferies E. (2009).
Lambon Ralph MA, Patterson K (2008).
Lambon Ralph MA, Lowe C, Rogers T. (2007).
Neural basis of category-specific semantic deficits for living things: evidence from semantic dementia, HSVE and a neural network model. Brain, 130( Pt 4), eScholarID:1d16008
Pobric GG, Jefferies E, Lambon Ralph MA. (2007).
Welbourne SR, Lambon Ralph MA. (2007).
Using PDP Models to Simulate Phonological Dyslexia: The Key Role of Plasticity-Related Recovery. Journal of Cognitive Neuroscience, 19 No 7, eScholarID:1d14146
Woollams AM, Lambon Ralph MA, D.C. Plaut, K. Patterson. (2007).
Crisp J, Lambon Ralph MA. (2006).
Unlocking the nature of the phonological-deep dyslexial continuum: the keys to reading aloud are in phonology and semantics. Journal of Cognitive Neuroscience, 18, eScholarID:1d26868 | DOI:10.1162/jocn.2006.18.3.348
Jefferies E, Lambon Ralph MA. (2006).
Semantic impairment in stroke aphasia versus semantic dementia: a case-series comparison. Brain, 129( Pt 8), eScholarID:1d16007
Lambon Ralph MA, Ehsan S. (2006).
Age of acquisition effects depend on the mapping between representations and the frequency of occurrence: Empirical and computational evidence. Visual Cognition, 13, eScholarID:1d8299
Patterson K, Lambon Ralph MA, Jefferies E, Woollams AM, Jones R, Hodges J. R, Rogers T. T. (2006).
'Pre-semantic' cognition in semantic dementia: Six deficits in search of an explanation. Journal of Cognitive Neuroscience, 18, eScholarID:1d9177
Lambon Ralph MA, Braber N, J.L. McClelland, K. Patterson. (2005).
What underlies the neuropsychological pattern of irregular > regular past-tense verb production? Brain & Language, 93, eScholarID:1d10369
Parker GJM, S. Luzzi, D.C. Alexander, C.A.M. Wheeler-Kingshott, O. Ciccarelli, Lambon Ralph MA. (2005).
Rogers T, Lambon Ralph MA, Garrard P, Bozeat S, McClelland J, Hodges J, Patterson K. (2004).
Bird H, Seidenberg MS, Lambon Ralph MA, McClelland J.L, Patterson K. (2003).
Deficits in phonology and past tense morphology. Journal of Memory and Language, 48, eScholarID:1d25768
Lambon Ralph MA, McClelland J, Patterson K, Galton C, Hodges J. (2001).
No right to speak? The relationship between object naming and semantic impairment: neuropsychological evidence and a computational model. J Cogn Neurosci, 13( 3), eScholarID:1d7558 | DOI:10.1162/08989290151137395
Patterson K, Lambon Ralph MA, Hodges J, McClelland J. (2001).
Deficits in irregular past-tense verb morphology associated with degraded semantic knowledge. Neuropsychologia, 39( 7), eScholarID:1d7559
Bozeat S, Lambon Ralph MA, Patterson K, Garrard P, Hodges J. (2000).
Non-verbal semantic impairment in semantic dementia. Neuropsychologia, 38( 9), eScholarID:1d7564
Ellis A, Lambon Ralph MA. (2000).
Age of acquisition effects in adult lexical processing reflect loss of plasticity in maturing systems: insights from connectionist networks. J Exp Psychol Learn Mem Cogn, 26( 5), eScholarID:1d7561
Patterson K, Lambon Ralph MA. (1999).
Selective disorders of reading? Current Opinion in Neurobiology, 9, 2, eScholarID:1d8278
Lambon Ralph MA, Howard D, Nightingale G, Ellis A. W. (1998).
Are living and non-living category-specific deficits casually linked to impaired perceptual or associative knowledge? Evidence from a category-specific double dissociation. Neurocase, 4, 4-5, eScholarID:1d8274